A NOVEL MACROLACTAM-DISACCHARIDE ANTIFUNGAL ANTIBIOTIC

TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES, STRUCTURE ELUCIDATION AND BIOLOGICAL ACTIVITY

Abstract

A novel natural product (1), with antifungal activity was isolated from the culture broth of an actinomadurae. The active compound was separated from broth by n-butanol extraction and purified by silica gel and multicoil counter current chromatography. Physico-chemical data suggested the structure of this compound to be a novel macrolactam disaccharide related to Sch 38518 (3). The structure was determined by spectroscopic studies on the acetate derivative. It was active against Candida spp. (MIC's, 4-64μg/ml) but less active than the monosaccharide, Sch 38518 (MIC's, 1-16μg/ml).