MILBEMYCINS α₁₁, α₁₂, α₁₃, α₁₄ and α₁₅: A NEW FAMILY OF MILBEMYCINS FROM Streptomyces hygroscopicus subsp. aureolacrimosus

TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES

Abstract

Streptomyces hygroscopicus subsp. aureolacrimosus SANK 60286 produces a new family of milbemycins, named milbemycins α₁₁, β₁₂, α₁₃, α₁₄ and α₁₅, together with other milbemycins. Their structures are 3-methyl-2-butenoyloxy and 3-methylbutyroyloxy derivatives at C-4a of milbemycins A3 and A4, or 3-methyl-2-pentenoyloxy derivative at C-4a of milbemycin A3, respectively. Milbemycin α₁₄, 3-methyl-2-butenoyloxy derivative, especially possesses a potent acaricidal activity.