MATLYSTATINS, NEW INHIBITORS OF TYPE IV COLLAGENASES FROM Actinomadura atramentaria III. STRUCTURE ELUCIDATION OF MATLYSTATINS A TO F

HIDEYUKI HARUYAMA; YOSHIKO OHKUMA; HIDEMI NAGAKI; TAKESHI OGITA; KAZUHIKO TAMAKI; TAKESHI KINOSHITA

doi:10.7164/antibiotics.47.1473

MATLYSTATINS, NEW INHIBITORS OF TYPE IV COLLAGENASES FROM Actinomadura atramentaria

III. STRUCTURE ELUCIDATION OF MATLYSTATINS A TO F

HIDEYUKI HARUYAMA, YOSHIKO OHKUMA, HIDEMI NAGAKI, TAKESHI OGITA, KAZUHIKO TAMAKI, TAKESHI KINOSHITA

Author information

JOURNAL FREE ACCESS

1994 Volume 47 Issue 12 Pages 1473-1480

DOI https://doi.org/10.7164/antibiotics.47.1473

Details

Abstract

The structures of matlystatins, novel type IV collagenase inhibitors isolated from Actinomadura atramentaria, have been determined by a systematic application of homo- and heteronuclear 2D NMR and FAB-MS/MS techniques. Their structures were characterized by the presence of piperazic acid and hydroxamic acid moieties, structural motifs often seen in protease inhibitors.

Corresponding author

Register with J-STAGE for free!