-ALKANOYL-5-HYDROXYMETHYL TETRONIC ACID HOMOLOGUES AND RESISTOMYCIN: NEW INHIBITORS OF HIV-1 PROTEASE I. FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITY

BARBARA E. ROGGO; FRANK PETERSEN; RON DELMENDO; HANS-BEAT JENNY; HEINRICH H. PETER; JOHANNES ROESEL

doi:10.7164/antibiotics.47.136

-ALKANOYL-5-HYDROXYMETHYL TETRONIC ACID HOMOLOGUES AND RESISTOMYCIN: NEW INHIBITORS OF HIV-1 PROTEASE

I. FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITY

BARBARA E. ROGGO, FRANK PETERSEN, RON DELMENDO, HANS-BEAT JENNY, HEINRICH H. PETER, JOHANNES ROESEL

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JOURNAL FREE ACCESS

1994 Volume 47 Issue 2 Pages 136-142

DOI https://doi.org/10.7164/antibiotics.47.136

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Abstract

In the course of a screening program for HIV-1 protease inhibiting activity, six new homologues of 3-alkanoyl-5-hydroxymethyl tetronic acids (1-6) and the known natural product resistomycin (7) were isolated from cultures of the Actinomycete strain DSM 7357. The substituted tetronic acids belong to a recently described structural class of secondary metabolites. The HIV-1 activity of resistomycin (7) has not been reported before.

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