The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
FUNGAL METABOLITES. Part 11. A POTENT IMMUNOSUPPRESSIVE ACTIVITY FOUND IN Isaria sinclairii METABOLITE
TETSURO FUJITAKENICHIRO INOUESATOSHI YAMAMOTOTAKESHI IKUMOTOSHIGEO SASAKIRYOUSUKE TOYAMAKENJI CHIBAYUKIO HOSHINOTAKEKI OKUMOTO
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1994 Volume 47 Issue 2 Pages 208-215

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Abstract

A potent immunosuppressive activity was found in the culture broth of the fungus Isaria sinclairii (ATCC 24400). The metabolite, ISP-I ((2S, 3R, 4R)-(E)-2-amino-3, 4-dihydroxy-2-hydroxymethyl-14-oxoeicos-6-enoic acid, myriocin = thermozymocidin) suppressed the proliferation of lymphocytes in mouse allogeneic mixed lymphocyte reaction, but had no effect on the growth of human tumor cell lines. It also suppressed the appearance of plaque-forming cells in response to sheep red blood cells and the generation of allo-reactive cytotoxic T lymphocytes in mice after intraperitoneal or oral administration. The metabolite was 10- to 100-fold more potent than cyclosporin A as an immunosuppressive agent of the immune responsein vivo, and in vivo, and appears to be a candidate for clinical application as a powerful immunosuppressant.

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