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The Journal of Antibiotics
Vol. 47 (1994) No. 2 P 216-224



In order to investigate the structure-activity relationships, fourteen derivatives of myriocin ((2S', 3R, 4R)-(E)-2-amino-3, 4-dihydroxy-2-hydroxymethyl-14-oxoeicos-6-enoic acid) were prepared and examined for immunosuppressive activity on mouse allogeneic mixed lymphocyte reaction in vitro. Among them, 14-deoxomyriocin ((2S, 3R, 4R)-(E)-2-amino-3, 4-dihydroxy-2-hydroxymethyl-eicos-6-enoic acid) was the most potent. It also suppressed the generation of allo-reactive cytotoxic T lymphocytes in mice upon intraperitoneal administration, with a potency 10-fold greater than that of myriocin.

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