BALHIMYCIN, A NEW GLYCOPEPTIDE ANTIBIOTIC PRODUCED BY Amycolatopsis sp. Y-86, 21022 TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITY

S. R. NADKARNI; M. V. PATEL; SUGATA CHATTERJEE; E. K. S. VIJAYAKUMAR; K. R. DESIKAN; J. BLUMBACH; B. N. GANGULI

doi:10.7164/antibiotics.47.334

BALHIMYCIN, A NEW GLYCOPEPTIDE ANTIBIOTIC PRODUCED BY Amycolatopsis sp. Y-86, 21022

TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITY

S. R. NADKARNI, M. V. PATEL, SUGATA CHATTERJEE, E. K. S. VIJAYAKUMAR, K. R. DESIKAN, J. BLUMBACH, B. N. GANGULI

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JOURNAL FREE ACCESS

1994 Volume 47 Issue 3 Pages 334-341

DOI https://doi.org/10.7164/antibiotics.47.334

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Abstract

A new glycopeptide antibiotic, balhimycin, has been isolated from the fermentation broth of a Amycolatopsis sp. Y-86, 21022. Balhimycin belongs to the vancomycin class of glycopeptides and contains a dehydrovancosamine sugar. The biological activity of balhimycin has been compared extensively with that of vancomycin against methicillin resistant staphylococci and also against anaerobes. Balhimycin is marginally superior to vancomycin in its in vitro activity against anaerobes and in its bactericidal properties.

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