FUNGAL METABOLITES. PART 14†. NOVEL POTENT IMMUNOSUPPRESSANTS, MYCESTERICINS, PRODUCED BY Mycelia sterilia

SHGEO SASAKI; RYOUTA HASHIMOTO; MASATOSHI KIUCHI; KENICHIRO INOUE; TAKESHI IKUMOTO; RYOJI HIROSE; KENJI CHIBA; YUKIO HOSHINO; TAKEKI OKUMOTO; TETSURO FUJITA

doi:10.7164/antibiotics.47.420

FUNGAL METABOLITES. PART 14†. NOVEL POTENT IMMUNOSUPPRESSANTS, MYCESTERICINS, PRODUCED BY Mycelia sterilia

SHGEO SASAKI, RYOUTA HASHIMOTO, MASATOSHI KIUCHI, KENICHIRO INOUE, TAKESHI IKUMOTO, RYOJI HIROSE, KENJI CHIBA, YUKIO HOSHINO, TAKEKI OKUMOTO, TETSURO FUJITA

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JOURNAL FREE ACCESS

1994 Volume 47 Issue 4 Pages 420-433

DOI https://doi.org/10.7164/antibiotics.47.420

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Abstract

Mycestericins A, B, C, D and E were isolated from the culture broth of Mycelia sterilia ATCC 20349 along with thermozymocidin (= myriocin). Their structures were elucidated on the basis of spectroscopic studies and chemical evidence. The acetate of mycestericin C was identical with the acetate of 6, 7-dihydromyriocin. Mycestericins suppressed the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction, with a potency similar to that of myriocin.

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