SYNTHESIS AND ANTICANDIDAL ACTIVITIES OF OPTIMIZED ANALOGS OF ANTIBIOTIC Sch 37137

Abstract

Peptide analogues of Sch 37137 the antifungal antibiotic have been synthesized and evaluated in vitro against Candida sp. Di- and tripeptides containing methionine, leucine, norvaline, lysine, glutamic acid and N³-(trans-epoxysuccmamoyl)-L-2, 3-diaminopropanoic acid, (EADP) were obtained. Peptides containing (d)-, and (L)-trans-epoxysuccinamic acid were also prepared. All of the analogues examined displayed in general higher anticandidal activity than a mixture of diastereomers of Sch 37137.