The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
DORRIGOCINS: NOVEL ANTIFUNGAL ANTIBIOTICS THAT CHANGE THE MORPHOLOGY OF ras-TRANSFORMEDNIH/3T3 CELLS TO THAT OF NORMAL CELLS
III. BIOLOGICAL PROPERTIES AND MECHANISM OF ACTION
SUNIL KADAMJAMES B. MCALPINE
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JOURNALS FREE ACCESS

1994 Volume 47 Issue 8 Pages 875-880

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Abstract

The dorrigocins are unique glutarimide antibiotics which were found to reverse the morphology of ras-transformed NIH/3T3 cells from a transformed phenotype to a normal one. The compounds also inhibited the release of yeast mating pheromone, a-factor. The activity of these compounds was not dependent on inhibition of prenylation or protein synthesis. Dorrigocin A was instead found to inhibit the carboxyl methylation in K-ras transformed cells.

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