The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
Gephyronic Acid, a Novel Inhibitor of Eukaryotic Protein Synthesis from Archangium gephyra (Myxobacteria)
Production, Isolation, Physico-chemical and Biological Properties, and Mechanism of Action
FLORENZ SASSEHEINRICH STEINMETZGERHARD HÖFLEHANS REICHENBACH
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1995 Volume 48 Issue 1 Pages 21-25

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Abstract

A new antibiotic compound, gephyronic acid was isolated from the culture broth of the myxobacterium, Archangium gephyra strain Ar 3895. Up to Smg/liter was produced during the logarithmic and stationary growth phase. The compound is an aliphatic acid, which tends to form a hemiacetal. Both forms inhibited growth of yeasts and molds (MIC 1-25μg/ml) and had a cytostatic effect on mammalian cell cultures (IC50 10-60ng/ml). Gephyronic acid is a specific inhibitor of eukaryotic protein sythesis showing an IC50 of 1-2 × 10-7mol/liter in an in vitro translation assay.

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