The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
Darlucins A and B, New Isocyanide Antibiotics from Sphaerellopsis filum (Darluca filum)
SYLVIA ZAPFMARTIN HOßFELDHEIDRUN ANKEROBERT VELTENWOLFGANG STEGLICH
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1995 Volume 48 Issue 1 Pages 36-41

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Abstract

Two new xanthocillin type antibiotics, darlucin A (1) and B (2), were isolated from fermentations of Sphaerellopsis filum (Darluca filum). Their structures were established by spectroscopic methods. The darlucins are the first known compounds with a 1, 2-diisocyanoalkene moiety. Both compounds exhibited antibacterial, antifungal and weak cytotoxic activities.

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