Terpendoles, Novel AC AT Inhibitors Produced by Albophoma yamanashiensis II. Structure Elucidation of Terpendoles A, B, C and D

XIN-HUI HUANG; HIROYUKI NISHIDA; HIROSHI TOMODA; NORIKO TABATA; KAZURO SHIOMI; DA-JUN YANG; HIROAKI TAKAYANAGI; SATOSHI OMURA

doi:10.7164/antibiotics.48.5

Terpendoles, Novel AC AT Inhibitors Produced by Albophoma yamanashiensis

II. Structure Elucidation of Terpendoles A, B, C and D

XIN-HUI HUANG, HIROYUKI NISHIDA, HIROSHI TOMODA, NORIKO TABATA, KAZURO SHIOMI, DA-JUN YANG, HIROAKI TAKAYANAGI, SATOSHI OMURA

Author information

XIN-HUI HUANG
Research Center for Biological Function, The Kitasato Institute, and School of Pharmaceutical Sciences, Kitasato University
HIROYUKI NISHIDA
Research Center for Biological Function, The Kitasato Institute, and School of Pharmaceutical Sciences, Kitasato University
Present address: Pfizer Central Research, Nagoya, Pfizer Pharmaceuticals Inc.
HIROSHI TOMODA
Research Center for Biological Function, The Kitasato Institute, and School of Pharmaceutical Sciences, Kitasato University
NORIKO TABATA
Research Center for Biological Function, The Kitasato Institute, and School of Pharmaceutical Sciences, Kitasato University
KAZURO SHIOMI
Research Center for Biological Function, The Kitasato Institute, and School of Pharmaceutical Sciences, Kitasato University
DA-JUN YANG
Research Center for Biological Function, The Kitasato Institute, and School of Pharmaceutical Sciences, Kitasato University
HIROAKI TAKAYANAGI
Research Center for Biological Function, The Kitasato Institute, and School of Pharmaceutical Sciences, Kitasato University
SATOSHI OMURA
Research Center for Biological Function, The Kitasato Institute, and School of Pharmaceutical Sciences, Kitasato University

JOURNAL FREE ACCESS

1995 Volume 48 Issue 1 Pages 5-11

DOI https://doi.org/10.7164/antibiotics.48.5

Details

Abstract

Structures of terpendoles A, B, C and D, novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors, were determined by spectroscopic studies. All terpendoles consist of diterpene and indole moieties in common. Terpendoles A, C and D possess an additional isoprenyl unit via oxygen atom(s) of their diterpene moieties. The relative stereochemistries of terpendoles C and D were confirmed by NOE experiments and X-ray crystallographic analysis.

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