Louisianins A, B, C and D: Non-steroidal Growth Inhibitors of Testosterone-responsive SC 115 Cells II. Physico-chemical Properties and Structural Elucidation

SATOSHI TAKAMATSU; YONG-PIL KIM; MASAHIKO HAYASHI; KIMIO FURUHATA; HIROAKI TAKAYANAGI; KANKI KOMIYAMA; H. BOYD WOODRUFF; SATOSHI OMURA

doi:10.7164/antibiotics.48.1090

Louisianins A, B, C and D: Non-steroidal Growth Inhibitors of Testosterone-responsive SC 115 Cells

II. Physico-chemical Properties and Structural Elucidation

SATOSHI TAKAMATSU, YONG-PIL KIM, MASAHIKO HAYASHI, KIMIO FURUHATA, HIROAKI TAKAYANAGI, KANKI KOMIYAMA, H. BOYD WOODRUFF, SATOSHI OMURA

Author information

SATOSHI TAKAMATSU
The Kitasato Institute and School of Pharmaceutical Sciences of Kitasato University
YONG-PIL KIM
The Kitasato Institute and School of Pharmaceutical Sciences of Kitasato University
MASAHIKO HAYASHI
The Kitasato Institute and School of Pharmaceutical Sciences of Kitasato University
KIMIO FURUHATA
The Kitasato Institute and School of Pharmaceutical Sciences of Kitasato University
HIROAKI TAKAYANAGI
The Kitasato Institute and School of Pharmaceutical Sciences of Kitasato University
KANKI KOMIYAMA
The Kitasato Institute and School of Pharmaceutical Sciences of Kitasato University
H. BOYD WOODRUFF
The Kitasato Institute and School of Pharmaceutical Sciences of Kitasato University
SATOSHI OMURA
The Kitasato Institute and School of Pharmaceutical Sciences of Kitasato University

JOURNAL FREE ACCESS

1995 Volume 48 Issue 10 Pages 1090-1094

DOI https://doi.org/10.7164/antibiotics.48.1090

Details

Abstract

New non-steroidal growth inhibitors of testosterone-responsive SC 1 15 cells, louisianins A (MW: 189; C₁₁H₁₁NO₂), B (MW: 191; C₁₁H₁₃NO₂), C (MW: 173; C₁₁H₁₁NO) and D (MW: 173; C₁₁H₁₁NO) were isolated from the cultured broth of Streptomyces sp. WK-4028. Their structures were determined on the basis of spectroscopic data. The structure of louisianin A in particular was confirmed by X-ray crystallographic analysis. The four compounds commonly possess a unique pyrindine skeleton in the molecule.

Corresponding author

Register with J-STAGE for free!