Phenopyrrozin, a New Radical Scavenger Produced by Penidllium sp. FO-2047

KAZURO SHIOMI; HONG YANG; Qi Xu; NORIKO ARAI; MIKIE NAMIKI; MASAHIKO HAYASHI; JUNJI INOKOSHI; HIDEO TAKESHIMA; ROKURO MASUMA; KANKI KOMIYAMA; SATOSHI OMURA

doi:10.7164/antibiotics.48.1413

Phenopyrrozin, a New Radical Scavenger Produced by Penidllium sp. FO-2047

KAZURO SHIOMI, HONG YANG, Qi Xu, NORIKO ARAI, MIKIE NAMIKI, MASAHIKO HAYASHI, JUNJI INOKOSHI, HIDEO TAKESHIMA, ROKURO MASUMA, KANKI KOMIYAMA, SATOSHI OMURA

Author information

KAZURO SHIOMI
Research Center for Biological Function, The Kitasato Institute
HONG YANG
Research Center for Biological Function, The Kitasato Institute
Qi Xu
Research Center for Biological Function, The Kitasato Institute
NORIKO ARAI
Research Center for Biological Function, The Kitasato Institute
MIKIE NAMIKI
Bio-Iatric Center, The Kitasato Institute
MASAHIKO HAYASHI
Research Center for Biological Function, The Kitasato Institute
JUNJI INOKOSHI
Research Center for Biological Function, The Kitasato Institute
HIDEO TAKESHIMA
Research Center for Biological Function, The Kitasato Institute
ROKURO MASUMA
Research Center for Biological Function, The Kitasato Institute
KANKI KOMIYAMA
Research Center for Biological Function, The Kitasato Institute
SATOSHI OMURA
Research Center for Biological Function, The Kitasato Institute

JOURNAL FREE ACCESS

1995 Volume 48 Issue 12 Pages 1413-1418

DOI https://doi.org/10.7164/antibiotics.48.1413

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Abstract

A new radical scavenger, named phenopyrrozin, was isolated from the culture broth of Penidllium sp. FO-2047. Phenopyrrozin was purified from whole broth by solvent extraction, silica gel chromatography, and HPLC. The structure of phenopyrrozin was elucidated as 5, 6, 7, 7a-tetrahydro2-hydroxy-l-phenyl-3H-pyrrolizin-3-one. The IC₅₀ of phenopyrrozin against lipid peroxidation induced by Cr₂K₂O₇ was 73μg/ml. Phenopyrrozin also reduced chromosomal aberrations induced by paraquat.

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