Rakicidins, New Cytotoxic Lipopeptides from Micromonospora sp. Fermentation, Isolation and Characterization

KIMBERLY D. MCBRIEN; RONALD L. BERRY; SUSAN E. LOWE; KIM M. NEDDERMANN; ISIA BURSUKER; STELLA HUANG; STEVEN E. KLOHR; JOHN E. LEET

doi:10.7164/antibiotics.48.1446

Rakicidins, New Cytotoxic Lipopeptides from Micromonospora sp. Fermentation, Isolation and Characterization

KIMBERLY D. MCBRIEN, RONALD L. BERRY, SUSAN E. LOWE, KIM M. NEDDERMANN, ISIA BURSUKER, STELLA HUANG, STEVEN E. KLOHR, JOHN E. LEET

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JOURNAL FREE ACCESS

1995 Volume 48 Issue 12 Pages 1446-1452

DOI https://doi.org/10.7164/antibiotics.48.1446

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Abstract

The new cytotoxic agents rakicidins A and B were isolated from cultured broth of a Micromonospora sp. Spectroscopic and amino acid analysis has shown that rakicidin A is a new cyclic lipopeptide, consisting of 4-amino-penta-2, 4-dienoic acid, 3-hydroxy-2, 4, 16-trimethylheptadecanoic acid, sarcosine, and 3-hydroxyasparagine. Rakicidin B differs by one methylene group in the lipid side chain. These compounds exhibited cytotoxicity against the Ml09 cell line.

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