Structure-antitumor Activity Relationship of Semi-synthetic Spicamycin Derivatives

TERUYUKI SAKAI; HIROYUKI KAWAI; MASARU KAMISHOHARA; ATSUO ODAGAWA; AKASHI SUZUKI; TAKESHI UCHIDA; TOMIKO KAWASAKI; TAKASHI TSURUO; NOBORU OTAKE

doi:10.7164/antibiotics.48.1467

TERUYUKI SAKAI, HIROYUKI KAWAI, MASARU KAMISHOHARA, ATSUO ODAGAWA, AKASHI SUZUKI, TAKESHI UCHIDA, TOMIKO KAWASAKI, TAKASHI TSURUO, NOBORU OTAKE

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JOURNAL FREE ACCESS

1995 Volume 48 Issue 12 Pages 1467-1480

DOI https://doi.org/10.7164/antibiotics.48.1467

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Abstract

New derivatives of spicamycin modified at the fatty acid moieties of the molecule were synthesized and their structure-activity relationships were examined. The antitumor activity was greatly influenced by modification of the fatty acid moieties to tetradecadienoyl or dodecadienoyl analogues exhibiting better antitumor activity against COL-1 human colon cancer xenograft than SPM VIII.

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