The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Azicemicins A and B, a New Antimicrobial Agent Produced by Amycolatopsis
I. Taxonomy, Fermentation, Isolation, Characterization and Biological Activities
TOSHIO TSUCHIDAHIRONOBU IINUMANAOKO KINOSHITATAKAKO IKEDATSUTOMU SAWAMASA HAMADATOMIO TAKEUCHI
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1995 Volume 48 Issue 3 Pages 217-221

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Abstract

A new structural class of the antibiotic, azicemicins A (1) and B (2) were isolated from the culture broth of the strain MJ126-NF4, which was closely related to Amycolatopsis sulphurea. They were purified by adsorption on Diaion HP-20, silica gel column chromatography and preparative TLC. The molecular formulas of 1 and 2 were determined to be C23H25O9N and C22H23O9N by HRFAB-MS, respectively. Azicemicins A and B have moderate growth inhibiting activity against Gram-positive bacteria and mycobacteria.

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