AKD-2A, B, C and D, New Antibiotics from Streptomyces sp. OCU-42815 Taxonomy, Fermentation, Isolation, Structure Elucidation and Biological Activity

YUKIHIRO AKEDA; KOZO SHIBATA; XU PING; TOSHIO TANAKA; MAKOTO TANIGUCHI

doi:10.7164/antibiotics.48.363

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

AKD-2A, B, C and D, New Antibiotics from Streptomyces sp. OCU-42815

Taxonomy, Fermentation, Isolation, Structure Elucidation and Biological Activity

YUKIHIRO AKEDA, KOZO SHIBATA, XU PING, TOSHIO TANAKA, MAKOTO TANIGUCHI

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JOURNAL FREE ACCESS

1995 Volume 48 Issue 5 Pages 363-368

DOI https://doi.org/10.7164/antibiotics.48.363

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Abstract

An antibiotic complex, AKD-2, was isolated from the mycelial cake of Streptomyces sp. OCU-42815. The lipophilic substances in this complex were further purified by a recycling HPLC procedure and were designated AKD-2A, C and D. AKD-2B was obtained as a mixture of AKD-2B₁ and AKD-2B₂. These substances were identified as monoglycerides having branched chain fatty acids and exhibited both antibacterial and antifungal activities.

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