A New Neuronal Cell Protecting Substance, Lavanduquinocin, Produced by Streptomyces viridochromogenes

KAZUO SHIN-YA; SHINTARO SHIMIZU; TOSHIHIRO KUNIGAMI; KEIKO FURIHATA; KAZUO FURIHATA; HARUO SETO

doi:10.7164/antibiotics.48.574

A New Neuronal Cell Protecting Substance, Lavanduquinocin, Produced by Streptomyces viridochromogenes

KAZUO SHIN-YA, SHINTARO SHIMIZU, TOSHIHIRO KUNIGAMI, KEIKO FURIHATA, KAZUO FURIHATA, HARUO SETO

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JOURNAL FREE ACCESS

1995 Volume 48 Issue 7 Pages 574-578

DOI https://doi.org/10.7164/antibiotics.48.574

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Abstract

A new neuronal cell protecting substance, lavanduquinocin was isolated from Streptomyces viridochromogenes 2942-SVS3. It consists of a carbazole skeleton with an ortho quinone function and a cyclolavandulyl moiety. Lavanduquinocin protected neuronal hybridoma N18-RE-105 cells from L-glutamate toxicity with EC₅₀ value 15.5nM.

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