Fusacandins A and B; Novel Antifungal Antibiotics of the Papulacandin Class from Fusarium sambucinum

I. Identity of the Producing Organism, Fermentation and Biological Activity

Abstract

The fusacandins, antifungal agents of the papulacandin class, are produced by a strain of Fusarium sambucinum. Fermentation yielded 60mg/liter of fusacandin A and minor amounts of fusacandin B. As expected, the fusacandins inhibit (1, 3)-β-glucan synthesis. Fusacandin A is slightly less active than papulacandin B against Candida albicans and, like papulacandin, loses activity in the presence of serum.