The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Microbial Conversion of Milbemycins: Oxidation of Milbemycin A4 and Related Compounds at the C-25 Ethy Group by Cirdnella umbellata and Absidia cylindrospora
KEIKO NAKAGAWAYOSHIHISA TSUKAMOTOKAZUO SATOAKIO TORIKATA
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1995 Volume 48 Issue 8 Pages 831-837

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Abstract

Microbial oxidation of milbemycin A4 at the C-25 ethyl group was performed. Milbemycin A4 was converted to 31- and 32-hydroxy derivatives by Cirdnella umbellata SANK 44272 along with 24- and 30-hydroxy derivatives. Related compounds, 5-ketomilbemycin A4 5-oxime and 13β-fluoromilbemycin A4 were similarly converted to the hydroxylated compounds by this microorganism. Absidia cylindrospora SANK 31472 converted milbemycin A4 to the corresponding 32-oic acid, 24-hydroxy derivative and a few oxygenated compounds including at the C-25 ethyl group.

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