The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
GERI-BP002-A, Novel Inhibitor of Acyl-CoA: Cholesterol Acyltransferase Produced by Aspergillus fumigatus F93
YOUNG-KOOK KIMHYUN-WOO LEEKWANG-HEE SONBYOUNG-MOG KWONTAE-SOOK JEONGDONG-HEUI LEEJONGHEON SHINYOUNGWAN SEOSUNG-UK KIMSONG-HAE BOK
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1996 Volume 49 Issue 1 Pages 31-36

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Abstract

A new inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), designated GERI-BP002-A, was isolated from the culture broth of Aspergillus fumigatus F93 by acetone extraction, EtOAc extraction, SiO2 column chromatography and reverse phase HPLC. Spectroscopic analyses of the compound identified bis (2-hydroxy-3-tert-butyl-5-methylphenyl) methane as the structure and its molecular weight and formula to be 340 and C23H32O2, respectively. GERI-BP002-A inhibited ACAT activity by 50% at the concentration of 50 μM in an enzyme assay system using rat liver microsomes.

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