A New Isopatulin Derivative Pintulin Produced by Penicillium vulpinum F-4148

Taxonomy, Isolation, Physico-chemical Properties, Structure and Biological Properties

Abstract

During our screening program of natural products from fungal metabolites for drugs effective against tumor cell lines, we discovered a new isopatulin derivative, pintulin, from the fermentation broth of Penicillium vulpinum F-4148. Pintulin shows weak activity against tumor cell lines, compared to that of adriamycin.