TMC-1 A, B, C and D, New Antibiotics of the Manumycin Group Produced by Streptomyces sp. Taxonomy, Production, Isolation, Physico-chemical Properties, Structure Elucidation and Biological Properties

JUN KOHNO; MAKI NISHIO; KIMIO KAWANO; NORIYUKI NAKANISHI; SHIN-ICHI SUZUKI; TOMOFUMI UCHIDA; SABURO KOMATSUBARA

doi:10.7164/antibiotics.49.1212

TMC-1 A, B, C and D, New Antibiotics of the Manumycin Group Produced by Streptomyces sp.

Taxonomy, Production, Isolation, Physico-chemical Properties, Structure Elucidation and Biological Properties

JUN KOHNO, MAKI NISHIO, KIMIO KAWANO, NORIYUKI NAKANISHI, SHIN-ICHI SUZUKI, TOMOFUMI UCHIDA, SABURO KOMATSUBARA

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JOURNAL FREE ACCESS

1996 Volume 49 Issue 12 Pages 1212-1220

DOI https://doi.org/10.7164/antibiotics.49.1212

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Abstract

Four new antitumor antibiotics, TMC-1 A, B, C and D were isolated from a fermentation broth of Streptomyces sp. A-230. Spectroscopic studies have shown that TMC-1 A to D were new members of the manumycin class of antibiotics. These antibiotics showed cytotoxic activities against various tumor cell lines in vitro.

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