Abstract
New isochromophilones VII and VIII were isolated from the culture broth of Penidllium sp. FO-4164. The structures were elucidated as 6H-2-benzopyran-6, 8(7H)-dione, 5-chloro-3-(3', 5'-dimethyl-1', 3'-heptadienyl)-1, 7, 8a-trihydro-7, 8a-dihydroxy-7-methyl-7-acetate for isochromophilone VII and 6H-2-benzopyran-6-one, 5-chloro-3-(3', 5'-dimethyl-1', 3'-heptadienyl)-1, 7, 8, 8a-tetrahydro-7, 8-dihydroxy-7-methyl-8-acetate for isochromophilone VIII. Isochromophilones VII and VIII inhibited diacylglycerol acyltransferase activity with IC50 values of 20.0 and 127 μM and acyl-CoA: cholesterol acyltransferase activity with IC50 values of 24.5 and 47.0 μM, respectively.
