Pyripyropenes, Novel AC AT Inhibitors Produced by Aspergillm fumigatus

IV. Structure Elucidation of Pyripyropenes M to R

Abstract

Six new pyripyropenes, M to R, were isolated from the ethyl acetate extracts of the jar fermentation broth of Aspergillus fumigatus FO-1289-2501. Structural elucidation indicated that all the pyripyropenes have the same pyridino-α-pyrone sesquiterpene core as pyripyropenes A to L. Among them pyripyropene M showed the most potent inhibition against acyl-CoA: cholesterol acyltransferase activity with an IC₅₀ value of 3.80μM in rat liver microsomes, but pyripyropenes N to R showed moderate inhibitory activity (IC₅₀ 11.0-78.0μM).