Chemistry of Pseudomonic Acid. Part 16 Aryl and Heteroaryl Ketone Derivatives of Monic Acid

ANGELA ABSON; NIGEL J. P. BROOM; PHILIPPA A. COATES; JOHN S. ELDER; ANDREW K. FORREST; PETER C. T. HANNAN; AMANDA J. HICKS; PETER J. O'HANLON; NICKY D. MASSON; NEIL D. PEARSON; JEAN E. PONS; JENNIFER M. WILSON

doi:10.7164/antibiotics.49.390

Chemistry of Pseudomonic Acid. Part 16

Aryl and Heteroaryl Ketone Derivatives of Monic Acid

ANGELA ABSON, NIGEL J. P. BROOM, PHILIPPA A. COATES, JOHN S. ELDER, ANDREW K. FORREST, PETER C. T. HANNAN, AMANDA J. HICKS, PETER J. O'HANLON, NICKY D. MASSON, NEIL D. PEARSON, JEAN E. PONS, JENNIFER M. WILSON

Author information

ANGELA ABSON
SmithKline Beecham Pharmaceuticals
NIGEL J. P. BROOM
SmithKline Beecham Pharmaceuticals
PHILIPPA A. COATES
SmithKline Beecham Pharmaceuticals
JOHN S. ELDER
SmithKline Beecham Pharmaceuticals
ANDREW K. FORREST
SmithKline Beecham Pharmaceuticals
PETER C. T. HANNAN
SmithKline Beecham Pharmaceuticals
AMANDA J. HICKS
SmithKline Beecham Pharmaceuticals
PETER J. O'HANLON
SmithKline Beecham Pharmaceuticals
NICKY D. MASSON
SmithKline Beecham Pharmaceuticals
NEIL D. PEARSON
SmithKline Beecham Pharmaceuticals
JEAN E. PONS
SmithKline Beecham Pharmaceuticals
JENNIFER M. WILSON
SmithKline Beecham Pharmaceuticals

JOURNAL FREE ACCESS

1996 Volume 49 Issue 4 Pages 390-394

DOI https://doi.org/10.7164/antibiotics.49.390

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Abstract

The synthesis, antibacterial activities, murine pharmacokinetic and infection model data for a range of aryl and heteroaryl ketone derivatives of monic acid (2a) are reported. The best results were found for the 3-furyl and 2-methoxy thiazol-5-yl analogues.

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