The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Novel Triterpene Sulfates from Fusarium compactum Using a Rhinovirus 3C Protease Inhibitor Screen
GREGORY M. BRILL, WARREN M. KATI, DEBRA MONTGOMERY, JAMES P. KARWOWSKI, PATRICK E. HUMPHREY, MARIANNA JACKSON, JACOB J. CLEMENT, SUNIL KADAM, RANDAL H. CHEN, JAMES B. MCALPINE
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1996 Volume 49 Issue 6 Pages 541-546

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Abstract

Two novel triterpene sulfates have been isolated from Fusarium compactum by bioactivitydirected fractionation using an assay which measures the inhibition of proteolytic activity of rhino virus 3C protease on a fluorogenic peptide substrate. The compounds were purified by countercurrent and reverse phase chromatographies. NMR, MS, UV and IR studies revealed two triterpene sulfates, uncommon metabolites of terrestrial fungi.

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The Journal of Antibiotics, Series A

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