Brasiliquinones A, B and C, New Benz[a]anthraquinone Antibiotics from Nocardia brasiliensis I. Producing Strain, Isolation and Biological Activities of the Antibiotics

AKIRA NEMOTO; YASUSHI TANAKA; YASUMI KARASAKI; HISAYUKI KOMAKI; KATSUKIYO YAZAWA; YUZURU MIKAMI; TAKASHI TOJO; KIYOSHI KADOWAKI; MASASHI TSUDA; KIYOSHI KADOWAKI

doi:10.7164/antibiotics.50.18

Brasiliquinones A, B and C, New Benz[a]anthraquinone Antibiotics from Nocardia brasiliensis

I. Producing Strain, Isolation and Biological Activities of the Antibiotics

AKIRA NEMOTO, YASUSHI TANAKA, YASUMI KARASAKI, HISAYUKI KOMAKI, KATSUKIYO YAZAWA, YUZURU MIKAMI, TAKASHI TOJO, KIYOSHI KADOWAKI, MASASHI TSUDA, KIYOSHI KADOWAKI

Author information

AKIRA NEMOTO
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
YASUSHI TANAKA
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
YASUMI KARASAKI
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
HISAYUKI KOMAKI
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
KATSUKIYO YAZAWA
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
YUZURU MIKAMI
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
TAKASHI TOJO
Higeta Shoyu Research Laboratory
KIYOSHI KADOWAKI
Higeta Shoyu Research Laboratory
MASASHI TSUDA
Faculty of Pharmaceutical Sciences, Hokkaido University
KIYOSHI KADOWAKI
Faculty of Pharmaceutical Sciences, Hokkaido University

JOURNAL FREE ACCESS

1997 Volume 50 Issue 1 Pages 18-21

DOI https://doi.org/10.7164/antibiotics.50.18

Details

Abstract

New benz[a]anthraquinone antibiotics (brasiliquinones A, B and C) with an ethyl group at C-3 were isolated. The producer was identified as Nocardia brasiliensis. The antibiotics were active against Gram-positive bacteria including Mycobacterium sp., but not active against Gram-negative bacteria or fungi. They were also active against multiple drug-resistant P388/ADR tumor cells.

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