Brasiliquinones A, B and C, New Benz[a]anthraquinone Antibiotics from Nocardia brasiliensis I. Producing Strain, Isolation and Biological Activities of the Antibiotics

AKIRA NEMOTO; YASUSHI TANAKA; YASUMI KARASAKI; HISAYUKI KOMAKI; KATSUKIYO YAZAWA; YUZURU MIKAMI; TAKASHI TOJO; KIYOSHI KADOWAKI; MASASHI TSUDA; KIYOSHI KADOWAKI

doi:10.7164/antibiotics.50.18

Brasiliquinones A, B and C, New Benz[a]anthraquinone Antibiotics from Nocardia brasiliensis

I. Producing Strain, Isolation and Biological Activities of the Antibiotics

AKIRA NEMOTO, YASUSHI TANAKA, YASUMI KARASAKI, HISAYUKI KOMAKI, KATSUKIYO YAZAWA, YUZURU MIKAMI, TAKASHI TOJO, KIYOSHI KADOWAKI, MASASHI TSUDA, KIYOSHI KADOWAKI

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JOURNAL FREE ACCESS

1997 Volume 50 Issue 1 Pages 18-21

DOI https://doi.org/10.7164/antibiotics.50.18

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Abstract

New benz[a]anthraquinone antibiotics (brasiliquinones A, B and C) with an ethyl group at C-3 were isolated. The producer was identified as Nocardia brasiliensis. The antibiotics were active against Gram-positive bacteria including Mycobacterium sp., but not active against Gram-negative bacteria or fungi. They were also active against multiple drug-resistant P388/ADR tumor cells.

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