The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
Pterulinic Acid and Pterulone, Two Novel Inhibitors of NADH: Ubiquinone Oxidoreductase (Complex I) Produced by a Pterula Species
II. Physico-chemical Properties and Structure Elucidation
MICHAELA ENGLERTIMM ANKEOLOV STERNER
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1997 Volume 50 Issue 4 Pages 330-333

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Abstract

The structures of two novel fungal antibiotics, isolated from a Pterula species, that interfere with the NADH: ubiquinone oxidoreductase and inhibit the respiration of eucaryotes, were determined by spectroscopic techniques. Both compounds, pterulinic acid (1a) and pterulone (2), contain a 1-benzoxepin ring system and are chlorinated. Pterulinic acid (1a), which was obtained as a 1:5 inseparable mixture of the two isomers (Z)-1a and (E)-1a, in addition contains a furan. Their structures were determined by mass spectrometry and NMR spectroscopy, and 2D heteronuclear correlation experiments permitted the assignment of all NMR signals.

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