TMC-2A, -2B and -2C, New Dipeptidyl Peptidase IV Inhibitors Produced by Aspergillus oryzae A374 II. Isolation and Structure Determination

YASUYUKI ASAI; NOBUAKI NONAKA; MAKI NISHIO; KIMIO OKAMURA; TADAMASA DATE; TAKAHISA SUGITA; TETSUO OHNUKI; SABURO KOMATSUBARA

doi:10.7164/antibiotics.50.653

TMC-2A, -2B and -2C, New Dipeptidyl Peptidase IV Inhibitors Produced by Aspergillus oryzae A374

II. Isolation and Structure Determination

YASUYUKI ASAI, NOBUAKI NONAKA, MAKI NISHIO, KIMIO OKAMURA, TADAMASA DATE, TAKAHISA SUGITA, TETSUO OHNUKI, SABURO KOMATSUBARA

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JOURNAL FREE ACCESS

1997 Volume 50 Issue 8 Pages 653-658

DOI https://doi.org/10.7164/antibiotics.50.653

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Abstract

New dipeptidyl peptidase IV inhibitors, TMC-2A, -2B, and -2C, were isolated from the fermentation broth of Aspergillus oryzae A374. On the basis of chemical, spectroscopic and X-ray crystallographic analyses, their structures were established to be peptide-like compounds composed of three moieties, L-tryptophan, mono- or dihydroxy-L-leucine and highly substituted isoquinoline.

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