Isolation and Characterization of a New Pyrano[4′, 3′:6, 7]naphtho[1, 2-b]xanthene Antibiotic FD-594

Abstract

During our screening of microbial metabolites for effective drugs against tumor cell lines, we discovered a new pyrano[4′, 3′:6, 7]naphtho[1, 2-b]xanthene derivative, FD-594 from the fermentation broth of Streptomyces sp. TA-0256. FD-594 shows moderate activity against tumor cell lines, comparative to that of adriamycin, as well as antibacterial activity against some Gram-positive bacteria.