Phosphatoquinones A and B, Novel Tyrosine Phosphatase Inhibitors Produced by Streptomyces sp.

TERUMI KAGAMIZONO; TAKUYA HAMAGUCHI; TSUTOMU ANDO; KOKO SUGAWARA; TAKASHI ADACHI; HIROYUKI OSADA

doi:10.7164/antibiotics.52.75

Phosphatoquinones A and B, Novel Tyrosine Phosphatase Inhibitors Produced by Streptomyces sp.

TERUMI KAGAMIZONO, TAKUYA HAMAGUCHI, TSUTOMU ANDO, KOKO SUGAWARA, TAKASHI ADACHI, HIROYUKI OSADA

Author information

JOURNAL FREE ACCESS

1999 Volume 52 Issue 2 Pages 75-80

DOI https://doi.org/10.7164/antibiotics.52.75

Details

Abstract

Phosphatoquinones A and B were isolated from the cultured broth of Streptomyces sp. TA-0363 and their structures were elucidated by spectroscopic analyses. Phosphatoquinones A and B inhibited the protein tyrosine phosphatase activity prepared from human Ball-1 cells with IC₅₀ of 28 μM and 2.9 μM, respectively.

Corresponding author

Register with J-STAGE for free!