TMC-66, a New Endothelin Converting Enzyme Inhibitor Produced by Streptomyces sp. A5008

YASUYUKI ASAI; NOBUAKI NONAKA; SHIN-ICHI SUZUKI; MAKI NISHIO; KOHEI TAKAHASHI; HIDEAKI SHIMA; KENJI OHMORI; TETSUO OHNUKI; SABURO KOMATSUBARA

doi:10.7164/antibiotics.52.607

TMC-66, a New Endothelin Converting Enzyme Inhibitor Produced by Streptomyces sp. A5008

YASUYUKI ASAI, NOBUAKI NONAKA, SHIN-ICHI SUZUKI, MAKI NISHIO, KOHEI TAKAHASHI, HIDEAKI SHIMA, KENJI OHMORI, TETSUO OHNUKI, SABURO KOMATSUBARA

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JOURNAL FREE ACCESS

1999 Volume 52 Issue 7 Pages 607-612

DOI https://doi.org/10.7164/antibiotics.52.607

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Abstract

A new endothelin converting enzyme (ECE) inhibitor, TMC-66 was isolated from the fermentation broth of Streptomyces sp. A5008. The structure of TMC-66 was elucidated by spectroscopic analyses to be a new member of benzo[a]naphthacenequinone class of antibiotics. TMC-66 had a highly selective inhibitory activity for ECE with an IC₅₀ value of 2.9μM. Taxonomy of the producing strain is also described.

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