New Cytotoxic AgentsvBE-54238A and B, Produced by a Streptomycete

MASAO TSUKAMOTO; SHIGERU NAKAJIMA; KUMIKO MUROOKA; MIOKO HIRAYAMA; KAORI HIRANO; SHIGEMI YOSHIDA; KATSUHISA KOJIRI; HIROYUKI SUDA

doi:10.7164/antibiotics.53.26

MASAO TSUKAMOTO, SHIGERU NAKAJIMA, KUMIKO MUROOKA, MIOKO HIRAYAMA, KAORI HIRANO, SHIGEMI YOSHIDA, KATSUHISA KOJIRI, HIROYUKI SUDA

Author information

MASAO TSUKAMOTO
Exploratory Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.
SHIGERU NAKAJIMA
Exploratory Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.
KUMIKO MUROOKA
Exploratory Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.
MIOKO HIRAYAMA
Exploratory Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.
KAORI HIRANO
Exploratory Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.
SHIGEMI YOSHIDA
Exploratory Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.
KATSUHISA KOJIRI
Exploratory Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.
HIROYUKI SUDA
Exploratory Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.

JOURNAL FREE ACCESS

2000 Volume 53 Issue 1 Pages 26-32

DOI https://doi.org/10.7164/antibiotics.53.26

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Abstract

New cytotoxic substances, designated BE-54238A and B, were isolated from the culture broth of Streptomyces sp. A54238. The active principles were extracted from the mycelium by methanol and purified by Diaion HP-20 and Sephadex LH-20 column chromatographies. BE-54238A and B exhibited cytotoxic activity against murine and human tumor cell lines.

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