The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
6-(Hydroxyalkyl)penicillanates as Probes for Mechanisms of β-Lactamases
DASANTILA GOLEMI, LAURENT MAVEYRAUD, AKIHIRO ISHIWATA, SAMUEL TRAMER, KAZUYUKI MIYASHITA, TSUYOSHI NAGASE, IRINA MASSOVA, LIONEL MOUREY, JEAN-PIERRE SAMAMA, SHAHRIAR MOBASHERY
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2000 Volume 53 Issue 10 Pages 1022-1027

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Abstract
6-(Hydroxyalkyl)penicillanates have proven helpful as probes for the mechanisms of β-lactamases, enzymes of resistance for β-lactam antibiotics. The present report summarizes the concepts on design, syntheses and use of these molecules in mechanistic studies of β-lactamases.
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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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