Arisostatins A and B, New Members of Tetrocarcin Class of Antibiotics from Micromonospora sp. TP-A0316 II. Structure Determination

YASUHIRO IGARASHI; KEIICHI TAKAGI; YUKIKO KAN; KIYONAGA FUJII; KEN-ICHI HARADA; TAMOTSU FURUMAI; TOSHIKAZU OKI

doi:10.7164/antibiotics.53.233

Arisostatins A and B, New Members of Tetrocarcin Class of Antibiotics from Micromonospora sp. TP-A0316

II. Structure Determination

YASUHIRO IGARASHI, KEIICHI TAKAGI, YUKIKO KAN, KIYONAGA FUJII, KEN-ICHI HARADA, TAMOTSU FURUMAI, TOSHIKAZU OKI

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JOURNAL FREE ACCESS

2000 Volume 53 Issue 3 Pages 233-240

DOI https://doi.org/10.7164/antibiotics.53.233

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Abstract

Structures of arisostatins A and B were determined by spectroscopic analyses. Arisostatins were found to be new analogs of tetrocarcin A and possess an iso-butanoyldigitoxose unit instead of the acetyldigitoxose one. NMR analyses of arisostatins and tetrocarcin A led to the revision of the anomeric configurations in the tetrasaccharide moiety of tetrocarcin A.

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