New Cytotoxic Agents, BE-52440A and B, Produced by a Streptomycete

MASAO TSUKAMOTO; SHIGERU NAKAJIMA; KUMIKO MUROOKA; MINORU NAITO; HAJIME SUZUKI; MIOKO HIRAYAMA; KAORI HIRANO; KATSUHISA KOJIRI; HIROYUKI SUDA

doi:10.7164/antibiotics.53.687

MASAO TSUKAMOTO, SHIGERU NAKAJIMA, KUMIKO MUROOKA, MINORU NAITO, HAJIME SUZUKI, MIOKO HIRAYAMA, KAORI HIRANO, KATSUHISA KOJIRI, HIROYUKI SUDA

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JOURNAL FREE ACCESS

2000 Volume 53 Issue 7 Pages 687-693

DOI https://doi.org/10.7164/antibiotics.53.687

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Abstract

New cytotoxic substances, designated BE-52440A and B, were isolated from the mycelium of Streptomyces sp. A52440. The active principles were extracted from the mycelium by methanol and purified by silica gel column chromatography. BE-52440A and B exhibited cytotoxic activity against murine and human tumor cell lines.

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