B-5354a, b and c, New Sphingosine Kinase Inhibitors, Produced by a Marine Bacterium; Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Structure Determination

Abstract

In the course of our screening for inhibitors of sphingosine kinase, we found a series of active compounds in a culture broth of a novel marine bacterium, SANK 71896. The structures of the compounds, named B-5354a, b and c, were elucidated by a combination of spectroscopic analyses to be new esters of 4-amino-3-hydroxybenzoic acid with long-chain unsaturated alcohols. B-5354a, b and c inhibit sphingosine kinase activity with IC₅₀ values of 21, 58 and 38 μM, respectively.