Novel Human Topoisomerase I Inhibitors, Topopyrones A, B, C and D II. Structure Elucidation

DAISUKE ISHIYAMA; YOSHINORI KANAI; HISATO SENDA; WAKAO IWATANI; HIROKO TAKAHASHI; HIROSHI KONNO; SUSUMU KANAZAWA

doi:10.7164/antibiotics.53.873

Novel Human Topoisomerase I Inhibitors, Topopyrones A, B, C and D

II. Structure Elucidation

DAISUKE ISHIYAMA, YOSHINORI KANAI, HISATO SENDA, WAKAO IWATANI, HIROKO TAKAHASHI, HIROSHI KONNO, SUSUMU KANAZAWA

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JOURNAL FREE ACCESS

2000 Volume 53 Issue 9 Pages 873-878

DOI https://doi.org/10.7164/antibiotics.53.873

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Abstract

The structures of novel topoisomerase I inhibitors, topopyrones A, B, C and D were elucidated by spectral analysis of the chemical derivatives. These compounds are an anthraquinone type containing a fused 1, 4-pyrone moiety. Topopyrones A and B contain a chlorine atom, however C and D do not. It was suggested that topopyrones B and D are converted from topopyrones A and C, respectively by Wessely-Moser type rearrangement.

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