4'-N-Methyl-5'-hydroxystaurosporine and 5'-Hydroxy staurosporine, New Indolocarbazole Alkaloids from a Marine Micromonospora sp. Strain

LIBRADA M. CAÑEDO HERNÁNDEZ; JESÚS ANGEL DE LA FUENTE BLANCO; JULIA PÉREZ BAZ; JOSÉ L. FERNÁNDEZ PUENTES; FRANCISCO ROMERO MILLÁN; FERNANDO ESPLIEGO VÁZQUEZ; ROSA ISABEL FERNÁNDEZ-CHIMENO; DOLORES GARCÍA GRÁVALOS

doi:10.7164/antibiotics.53.895

4'-N-Methyl-5'-hydroxystaurosporine and 5'-Hydroxy staurosporine, New Indolocarbazole Alkaloids from a Marine Micromonospora sp. Strain

LIBRADA M. CAÑEDO HERNÁNDEZ, JESÚS ANGEL DE LA FUENTE BLANCO, JULIA PÉREZ BAZ, JOSÉ L. FERNÁNDEZ PUENTES, FRANCISCO ROMERO MILLÁN, FERNANDO ESPLIEGO VÁZQUEZ, ROSA ISABEL FERNÁNDEZ-CHIMENO, DOLORES GARCÍA GRÁVALOS

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JOURNAL FREE ACCESS

2000 Volume 53 Issue 9 Pages 895-902

DOI https://doi.org/10.7164/antibiotics.53.895

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Abstract

Two new indolocarbazole alkaloids, 4'-N-methyl-5'-hydroxystaurosporine (2) and 5'-hydroxystaurosporine (3), were isolated together with the known staurosporine (1) from the culture broth of a marine Micromonospora sp. (strain L-31-CLCO-002). The fermentation, structural data and cytotoxic activities of these compounds against various tumor cell lines are given.

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