FR901469, a Novel Antifimgal Antibiotic from an Unidentified Fungus No.11243 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties

AKIHIKO FUJIE; TOSHIRO IWAMOTO; HIDEYUKI MURAMATSU; TERUMI OKUDAIRA; KUMIKO NITTA; TOMOKO NAKANISHI; KAZUTOSHI SAKAMOTO; YASUHIRO HORI; MOTOHIRO HINO; SEIJI HASHIMOTO; MASAKUNI OKUHARA

doi:10.7164/antibiotics.53.912

FR901469, a Novel Antifimgal Antibiotic from an Unidentified Fungus No.11243

I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties

AKIHIKO FUJIE, TOSHIRO IWAMOTO, HIDEYUKI MURAMATSU, TERUMI OKUDAIRA, KUMIKO NITTA, TOMOKO NAKANISHI, KAZUTOSHI SAKAMOTO, YASUHIRO HORI, MOTOHIRO HINO, SEIJI HASHIMOTO, MASAKUNI OKUHARA

Author information

AKIHIKO FUJIE
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
TOSHIRO IWAMOTO
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
HIDEYUKI MURAMATSU
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
TERUMI OKUDAIRA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
KUMIKO NITTA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
TOMOKO NAKANISHI
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
KAZUTOSHI SAKAMOTO
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
YASUHIRO HORI
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MOTOHIRO HINO
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
SEIJI HASHIMOTO
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MASAKUNI OKUHARA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

JOURNAL FREE ACCESS

2000 Volume 53 Issue 9 Pages 912-919

DOI https://doi.org/10.7164/antibiotics.53.912

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Abstract

FR901469 is a novel antifungal antibiotic produced by an unidentified fungus No.11243. This compound was isolated from the culture broth by solvent extraction, HP-20 and YMC ODS gel column chromatography, and lyophilization. FR901469 is a white powder which melts at 182-187°C and possesses the molecular formula C₇₁H₁₁₆N₁₄O₂₃. This compound has good water solubility. FR901469 inhibited the activity of 1, 3-β-glucan synthase from Candida albicans with an IC₅₀ value of 0.05μg/ml, and displayed greater inhibitory activity than other 1, 3-β-glucan synthase inhibitors such as, WF11899A, echinocandin B, aculeacin A, and papulacandin B.

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