Isolation, and Biological Properties of a New Cell Cycle Inhibitor, Curvularol, Isolated from Curvularia sp. RK97-F166

YOKO HONDA; MASASHI UEKI; GEN OKADA; RIE ONOSE; RON USAMI; KOKI HORIKOSHI; HIROYUKI OSADA

doi:10.7164/antibiotics.54.10

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

Isolation, and Biological Properties of a New Cell Cycle Inhibitor, Curvularol, Isolated from Curvularia sp. RK97-F166

YOKO HONDA, MASASHI UEKI, GEN OKADA, RIE ONOSE, RON USAMI, KOKI HORIKOSHI, HIROYUKI OSADA

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2001 Volume 54 Issue 1 Pages 10-16

DOI https://doi.org/10.7164/antibiotics.54.10

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Abstract

A new cell growth inhibitor, curvularol, was isolated from the fermentation broth of Curvularia sp. RK97-F166. Curvularol showed no antibacterial activity, and very weak antifungal activity. However, curvularol inhibited the cell cycle progression of normal rat kidney (NRK) cells in G₁ phase at 150ng/ml. Curvularol induced the morphological reversion of src^ts-transformed NRK cells at 100ng/ml, and inhibited protein synthesis same as cycloheximide.

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