Neuroprotectins A and B, Bicyclohexapeptides Protecting Chick Telencephalic Neurons from Excitotoxicity II. Structure Determination

HIROYUKI KOBAYASHI; KAZUO SHIN-YA; KAZUO FURIHATA; KOJI NAGAI; KEN-ICHI SUZUKI; YOICHI HAYAKAWA; HARUO SETO; BONG-SIK YUN; IN-JA RYOO; JUNG-SIK KIM; CHANG-JIN KIM; ICK-DONG YOO

doi:10.7164/antibiotics.54.1019

Neuroprotectins A and B, Bicyclohexapeptides Protecting Chick Telencephalic Neurons from Excitotoxicity

II. Structure Determination

HIROYUKI KOBAYASHI, KAZUO SHIN-YA, KAZUO FURIHATA, KOJI NAGAI, KEN-ICHI SUZUKI, YOICHI HAYAKAWA, HARUO SETO, BONG-SIK YUN, IN-JA RYOO, JUNG-SIK KIM, CHANG-JIN KIM, ICK-DONG YOO

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JOURNAL FREE ACCESS

2001 Volume 54 Issue 12 Pages 1019-1024

DOI https://doi.org/10.7164/antibiotics.54.1019

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Abstract

In the course of our search for neuroprotective agents of microbial origin against kainateinduced neurotoxicity, we have succeeded in the isolation of two new bicyclohexapeptides, neuroprotectins A and B, together with a known compound, complestatin, from the fermentation broth of Streptomyces sp. Q27107. They are closely related in structure to complestatin and possess an oxindolylalanine moiety in place of the tryptophan residue present in complestatin.

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