CJ-19, 784, a New Antifungal Agent from a Fungus, Acanthostigmella sp.

SHUZO WATANABE; HIDEO HIRAI; YOSHINAO KATO; HIROYUKI NISHIDA; TOSHIYUKI SAITO; NOBUJI YOSHIKAWA; TANYA PARKINSON; YASUHIRO KOJIMA

doi:10.7164/antibiotics.54.1031

CJ-19, 784, a New Antifungal Agent from a Fungus, Acanthostigmella sp.

SHUZO WATANABE, HIDEO HIRAI, YOSHINAO KATO, HIROYUKI NISHIDA, TOSHIYUKI SAITO, NOBUJI YOSHIKAWA, TANYA PARKINSON, YASUHIRO KOJIMA

Author information

SHUZO WATANABE
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
HIDEO HIRAI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
YOSHINAO KATO
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
HIROYUKI NISHIDA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
TOSHIYUKI SAITO
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
NOBUJI YOSHIKAWA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
TANYA PARKINSON
PGRD, Sandwich Laboratories, Pfizer Inc.
YASUHIRO KOJIMA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.

JOURNAL FREE ACCESS

2001 Volume 54 Issue 12 Pages 1031-1035

DOI https://doi.org/10.7164/antibiotics.54.1031

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Abstract

A new antifimgal agent, CJ-19, 784 (I), was isolated from the fermentation broth of a fungus, Acanthostigmella sp. CL12082. Based on spectroscopic analyses, structure of I was determined to be 3'-bromo-2', 5-dihydroxy-3, 7, 8-trimethoxy-flavone. Compound I inhibits the growth of pathogenic fungi, Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus with IC₅₀ values of 0.11, 20 and 0.54 μg/ml, respectively.

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