Synthesis and Antibacterial Activity of Novel 1β-Methyl Carbapenems with Cycloalkylamine Moiety at the C-2 Position

ISAO KAWAMOTO; YASUO SHIMOJI; OSAMU KANNO; ROKURO ENDO; MASAO MIYAUCHI; KATSUHIKO KOJIMA; KATSUYA ISHIKAWA; MUNETSUGU MORIMOTO; SATOSHI OHYA

doi:10.7164/antibiotics.54.1080

ISAO KAWAMOTO, YASUO SHIMOJI, OSAMU KANNO, ROKURO ENDO, MASAO MIYAUCHI, KATSUHIKO KOJIMA, KATSUYA ISHIKAWA, MUNETSUGU MORIMOTO, SATOSHI OHYA

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JOURNAL FREE ACCESS

2001 Volume 54 Issue 12 Pages 1080-1092

DOI https://doi.org/10.7164/antibiotics.54.1080

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Abstract

Novel 1β-methyl carbapenems with a cycloalkylamine moiety as a side chain were synthesized and their structure-activity relationships were studied. These carbapenems showed potent antibacterial activities against a wide range of Gram-positive and Gram-negative bacteria, and moderate urinary recovery when administered intraperitoneally in mice.

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