FR198248, a New Anti-influenza Agent Isolated from Aspergillus terreus No. 13830 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities

YUTAKA NISHIHARA; EISAKU TSUJII; YUKIKO YAMAGISHI; KAZUTOSHI SAKAMOTO; YASUHISA TSURUMI; SHIGETADA FURUKAWA; REIKO OHTSU; TORU KINO; MOTOHIRO HINO; MICHIO YAMASHITA; SEUI HASHIMOTO

doi:10.7164/antibiotics.54.136

FR198248, a New Anti-influenza Agent Isolated from Aspergillus terreus No. 13830

I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities

YUTAKA NISHIHARA, EISAKU TSUJII, YUKIKO YAMAGISHI, KAZUTOSHI SAKAMOTO, YASUHISA TSURUMI, SHIGETADA FURUKAWA, REIKO OHTSU, TORU KINO, MOTOHIRO HINO, MICHIO YAMASHITA, SEUI HASHIMOTO

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2001 Volume 54 Issue 2 Pages 136-143

DOI https://doi.org/10.7164/antibiotics.54.136

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Abstract

A novel anti-influenza agent, FR198248, was isolated from the cultured broth of a fungal strain No. 13830. The strain was identified as Aspergillus terreus from morphological characteristics. FR198248, a new type of hydroxyl benzaldehyde compound, showed anti-influenza virus activity in Madin-Darby canine kidney (MDCK) cells in vitro. The mode of action of FR198248 against influenza virus A could be ascribed to an inhibitory effect on the stage of virus adsorption. Furthermore, FR198248 possessed potent in vivo anti-influenza activity in a murine model of respiratory tract infection.

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