Haliangicin, a Novel Antifungal Metabolite Produced by a Marine Myxobacterium

1. Fermentation and Biological Characteristics

Abstract

Haliangicin, a novel β-methoxyacrylate antibiotic with a conjugated tetraene moiety, was isolated from the culture broth of a marine myxobacterium. A bacterium tentatively named as Haliangium luteum required 2-3% NaCl for the growth and production of haliangicin. Haliangicin inhibits the growth of a wide spectrum of fungi but was inactive against bacteria. In mitochondrial respiratory chains, haliangicin interfered the electron flow within the cytochrome b-c1 segment.