Synthesis and Biological Evaluation of Cytogenin Derivatives

NAOKI MATSUMOTO; TAKASHI NAKASHIMA; KUNIO ISSHIKI; HIROSHI KUBOKI; SHIN-ICHI HIRANO; HLROYUKI KUMAGAI; TAKEO YOSHIOKA; MASAAKI ISHIZUKA; TOMIO TAKEUCHI

doi:10.7164/antibiotics.54.285

NAOKI MATSUMOTO, TAKASHI NAKASHIMA, KUNIO ISSHIKI, HIROSHI KUBOKI, SHIN-ICHI HIRANO, HLROYUKI KUMAGAI, TAKEO YOSHIOKA, MASAAKI ISHIZUKA, TOMIO TAKEUCHI

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JOURNAL FREE ACCESS

2001 Volume 54 Issue 3 Pages 285-296

DOI https://doi.org/10.7164/antibiotics.54.285

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Abstract

To enhance the stability in vivo, new derivatives of cytogenin were synthesized, and their biological activity and stability in mice were estimated. 2-(8-Hydroxy-6-methoxy-l-oxo-1H-2-benzopyran-3-yl)propionic acid (NM-3) was found to be the most stable among them. It modified collagen-induced arthritis in mice. It also showed potent anti-angiogenic activity in a mouse dorsal air sac assay.

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